YMC America becomes first U.S. supplier of ASME U-stamped DAC columns

YMC America says its Devens, Massachusetts facility can now supply ASME U-stamped Dynamic Axial Compression columns for pharmaceutical manufacturing. The move gives peptide, oligonucleotide and small-molecule API makers a domestically supported, code-compliant option for chromatography systems.

Why it matters: - YMC America’s U.S. manufacturing expansion gives drugmakers a domestic source for ASME U-stamped DAC columns. - The systems are used in peptide, oligonucleotide and small-molecule API production, where supply chain reliability and compliance matter. - The company says the move can improve timelines, reliability and U.S. supply chain resilience for critical drug-manufacturing equipment.

What happened: - YMC America expanded its Devens, Massachusetts operations to supply ASME U-Stamped Dynamic Axial Compression columns. - The company says it is the first known U.S.-based supplier of these systems for pharmaceutical manufacturing. - The expanded capability covers columns assembled, inspected and pressure tested in the United States under YMC America’s ASME-approved quality program. - The company’s current DAC column sizes are 300, 450 and 600 mm inner diameters. - 800 mm and 1,000 mm models are planned for future availability.

The details: - YMC America’s ASME Certificate of Authorization confirms the Devens facility meets ASME Boiler and Pressure Vessel Code requirements. - DAC columns supplied from the facility are eligible to bear the ASME U-Stamp. - YMC America designs its DAC columns to ASME Section VIII, Division 1 requirements. - The company operates under an active ASME Certificate of Authorization for U and R Stamp activities. - Each column is assembled, inspected and pressure tested at Devens with required documentation and National Board registration provided. - The company says all ASME-required quality and compliance activities are conducted within its certified U.S. facility. - YMC America’s DAC columns support process development through commercial production. - The systems are used in laboratory, pilot and production-scale chromatography applications. - The columns are used for purification processes involving peptides, oligonucleotides and small-molecule APIs. - Dynamic Axial Compression technology keeps pressure consistent on the chromatography bed during operation. - The technology is designed to support reproducible packing performance and efficient media utilization. - Key features include self-packing design, an optional slurry container for automated hygienic packing procedures, support for IQ/OQ qualification and explosion-proof operation.

Between the lines: - The U-Stamp gives YMC America a compliance and sourcing advantage in a market where domestic support can shorten lead times and reduce cross-border dependencies. - The launch also positions the company to serve regulated pharmaceutical customers that need documented quality controls and pressure-vessel certification. - The planned larger column sizes suggest YMC America is targeting broader process scales beyond current models.

What's next: - YMC America plans to add 800 mm and 1,000 mm DAC column models in the future. - Customers seeking more information can visit the DAC columns page or contact sales@ymcamerica.com. - YMC America will continue supporting chromatography, purification and related services through its Devens base and global subsidiary network.

The bottom line: - YMC America now offers a U.S.-supplied, ASME U-stamped chromatography option for manufacturers that want domestic support and code-compliant equipment.